Dr. Simon's LinkedIn and ResearchGate profiles.


  1. Bodek, A. and Simon, A. What do Electron and Neutrino Experiments Tell About Nuclear Effects in the Deuteron?Phys. C 29: 231 (1985).
  2. Simon, A. J., Bechhoefer, J., and Libchaber, A. Solitary Modes and the Eckhaus Instability in Directional Solidification. Phys. Rev. Lett. 61: 2574 (1988).
  3. Bechhoefer, J., Simon, A. J., Libchaber, A, and Oswald, P. Destabilization of a flat nematic-isotropic interface. Phys. Rev. A 40: 2042 (1989).
  4. Berge, B., Simon, A. J., and Libchaber, A. Dynamics of gas bubbles in monolayers. Phys. Rev. A15 41: 6893 (1990).
  5. Simon, A. J., and Libchaber, A. Moving Interface:  The stability tongue and phenomena within. Phys. Rev. A15 41: 7090 (1990).
  6. Molho, P., Simon, A. J., and Libchaber, A. Péclet number and crystal growth in a channel. Phys. Rev. A15 42: 904 (1990).
  7. Flesselles, J-M., Simon, A. J.,  and Libchaber, A. Dynamics of one-dimensional interfaces:  an experimentalist's view. Adv. in Phys. 40: 1 (1991).
  8. Simon, A. J. and Libchaber, A. Escape and Synchronization of a Brownian Particle. Phys. Rev. Lett.  68: 3375 (1992).
  9. Ott, A., Magnasco, M., Simon, A. J., and Libchaber, A. Measurement of the persistence length of polymerized actin using fluorescence microscopy. Phys. Rev. E 48: R1642 (1993).
  10. Bensimon, A., Simon, A. J., Chiffaudel, A., Croquette, V., Heslot, F., Bensimon, D. Alignment and Sensitive Detection of DNA by a moving meniscus. Science 265: 2096 (1994).
  11. Bensimon, D, Simon, AJ, Croquette, V, Bensimon, A. Stretching DNA by a receding meniscus:  Experiments and models. Phys. Rev. Lett. 74: 4754 (1995).
  12. Barouch, D. H., Santra, S., Schmitz, J. E., Kuroda, M. J., Fu, T. M., Wagner, W., Bilska, M., Craiu, A., Zheng, X. X., Krivulka, G. R., Beaudry, K., Lifton, M. A., Nickerson, C. E., Trigona, W. L., Punt, K., Freed, D. C., Guan, L., Dubey, S., Casimiro, D., Simon, A., Davies, M. E., Chastain, M., Strom, T. B., Gelman, R. S., Montefiori, D. C., Lewis, M. G., Emini, E. A., Shiver, J. W., Letvin, N. L. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290 (5491): 486 (2000).
  13. Zucchelli, S., Capone, S., Fattori, E., Folgori, A., Di Marco, A., Casimiro, D., Simon, A. J., Laufer, R., La Monica, N., Cortese, R., Nicosia, A. Enhancing B  and T cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol. 74 (24): 11598 (2000).
  14. Chastain, M., Simon, A. J., Soper, K. A, Holder, D. J., Montgomery, D. L., Sagar, S. L., Casimiro, D. R., Middaugh, C. R. Antigen levels and antibody titers after DNA vaccination. Pharm. Sci. 90 (4): 474 (2001).
  15. Casimiro, D., Tang, A., Perry, H. C., Long, R. S., Chen, M, Heidecker, G. J., Davies, M. E., Freed, D. C., Persaud, N. V., Dubey, S., Smith, J. G., Havlir, D., Richman, D., Chastain, M. A., Simon, A. J., Fu, T. M., Emini, E. A., Shiver, J. W. Vaccine-induced immune responses in rodents and nonhuman primates by use of a humanized human immunodeficiency virus type 1 pol gene. Virol. 76 (1): 185 (2002).
  16. Shiver, J. W., Fu, T-M., Chen, L., Casimiro, D. R., Davies, M. E., Evans, R. K., Zhang, Z-Q., Simon, A. J., Trigona, W. L., Dubey, S. A., Huang, L., Harris, V. A., Long, R. S., Liang, X., Handt, L., Schleif, W. A., Zhu, L., Freed, D. C., Persaud, N. V., Guan, L., Punt, K. S., Tang, A., Chen, M., Wilson, K. A., Collins, K. B., Heidecker, G. J., Fernandez, V. R., Perry, H. C., Joyce, J. G., Grimm, K. M., Cook, J. C., Keller, P. M., Kresock, D. S., Mach, H., Troutman, R. D., Isopi, L. A., Williams D. M., Xu, Z., Bohannon, K. E., Volkin, D. B., Montefiori, D. C., Miura, A., Krivulka, G. R., Lifton, M. A., Kuroda, M. J., Schmitz, J. E., Letvin, N. L., Caulfield, M. J., Bett, A. J., Youil, R., Kaslow, D. C., Emini, E. A. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415: 331 (2002).
  17. Lineberger, J. E., Danzeisen, R., Hazuda, D. J., Simon, A. J., Miller, M. D. Altering expression levels of human immunodeficiency virus type 1 gp120-gp41 affects efficiency but not kinetics of cell-cell fusion. Virol. 76 (7): 3522 (2002).
  18. Caulfield, M. J., Wang, S., Smith, J.G., Tobery, T.W., Liu, X., Davies, M.E., Casimiro, D.R., Fu, T.M., Simon, A., Evans,R.K., Emini, E.A., Shiver, J. Sustained peptide-specific gamma interferon T-cell response in rhesus macaques immunized with human immunodeficiency virus gag DNA vaccines. Virol. 76 (19): 10038 (2002).
  19. Lamartina, S., Silvi, L., Roscilli, G., Casimiro, D., Simon, A.J., Davies, M.E., Shiver, J.W., Rinaudo, C.D., Zampaglione, I., Fattori, E., Colloca, S., Paz, O.G., Laufer, R., Bujard, H., Cortese, R., Ciliberto, G., Toniatti, C. Construction of an rtTA2(s)-m2/tts(kid)-Based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and Non-human Primates. Mol. Ther. 7 (2): 271 (2003).
  20. Murray, E.M., Grobler, J.A., Markel, E.J., Pagnoni, M.F., Paonessa, G., Simon, A.J., Flores, O.A. Persistent Replication of Hepatitis C Virus Replicons Expressing the beta-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells. Virol. 77 (5): 2928 (2003).
  21. Zuck, P., Murray, E.M., Stec, E., Grobler, J.A., Simon, A.J., Strulovici, B., Inglese, J., Flores, O.A., Ferrer, M. A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication. Analytical Biochemistry 334: 344-355 (2004).
  22.  Stachel, S.J., Coburn, C.A., Steele, T., Jones, K.G., Loutzenhiser, E., Gregro, A.R., Rajapakse, H.A., Lai, M., Crouthamel, M.C., Xu, M., Tugusheva, K., Lineberger, J.E., Pietrak, B.L., Espeseth, A.S., Shi, X., Holloway, M.K., Munshi, S.K., Simon, A.J., Kuo, L.C., Vacca, J.P. Structure-Based Design of a Series of Potent and Selective Cell-Permeable Inhibitors of Human beta-Secretase (BACE-1). Med. Chem. 47 (26): 6447-50 (2004).
  23. Brandish, P.E., Su, M., Holder, D.J., Hodor, P., Szumiloski, J., Kleihanz, R.R., Forbes, J.E., McWhorter, M.M., Duenwald, S.J., Parrish, M.L., Na, S., Liu, Y., Phillips, R.L., Renger, J.J., Sankaranarayanan, S., Simon, A.J., Scolnick, E.M. Regulation of gene expression by lithium and depletion of inositol in slices of adult  rat cortex. Neuron. 45 (6): 861-72 (2005).
  24. Espeseth, A.S., Xu, M., Huang, Q., Coburn, C.A., Jones, K.L.G., Ferrer, M., Zuck, P.D., Strulovic, B., Price, E.A., Wu, G.X., Wolfe, A.L., Lineberger, J.E., Sardana, M., Tugusheva, K., Pietrak, B.L., Crouthamel, M.C., Lai, M.T., Dodson, E.C., Bazzo, R., Shi, X.P., Simon, A.J., Li, Y.M, Hazuda, D.J. Compounds that bind APP and inhibit A-beta processing in vitro suggest a novel approach to Alzheimer disease therapeutics. Biol Chem. 280 (18): 17792-17797 (2005).
  25. Shi, X., Tugusheva, K., Bruce, J.E., Lucka, A., Chen-Dodson, E.C., Hu, B., Wu, G., Price, E., Register, R.B., Lineberger, J., Gates, A.T., Miller, R., Tang, M., Espeseth, A., Kahana, J., Wolfe, A., Crouthamel, M., Sankaranarayanan, S., Simon, A., Chen, L., Lai, M.-T., Pietrak, B., Dimuzio-Mower, J., Li, Y., Xu, M., Huang, Q., Garsky, V., Sardana, M.K., Hazuda, D.J. Novel mutations introduced at the beta-site of amyloid precursor protein enhance the production of amyloid beta peptide by BACE1 in vitro and in cells” Alzheimer’s Disease 7 (2): 139-148 (2005).
  26. Pietrak, B.L., Crouthamel, M.C., Tugusheva, K., Lineberger, J.E., Xu, M., DiMuzio, J.M., Steele, T., Espeseth, A.S., Stachel, S.J., Coburn, C.A., Graham, S.L., Vacca, J.P., Shi, X.P., Simon, A.J., Hazuda, D.J., Lai, M.T. Biochemical and cell-based assays for characterization of BACE-1 inhibitors. Anal Biochem. 342 (1): 144-51 (2005).
  27. Coburn, C.A., Stachel, S.J., Jones, K.G., Steele, T.G., Rush, D.M., DiMuzio, J., Pietrak, B.L., Lai, M.T., Huang, Q., Lineberger, J., Jin, L., Munshi, S., Holloway, K. M., Espeseth, A., Simon, A., Hazuda, D., Graham, S.L., Vacca, J.P. BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres. Bioorg Med Chem Lett. 16 (14): 3635-8 (2006).
  28. Espeseth, A.S., Huang, Q., Gates, A., Xu, M., Yu, Y., Simon, A.J., Shi, X.P., Zhang, X., Hodor, P., Stone, D.J., Burchard, J., Cavet, G., Bartz, S., Linsley, P., Ray, W.J., Hazuda, D. A genome-wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Mol Cell Neurosci. 33 (3): 227-35 (2006)..
  29. Stachel, S.J., Coburn, C.A., Sankaranarayanan, S., Price, E.A., Wu, G., Crouthamel, M., Pietrak, B.L., Huang, Q., Lineberger, J., Espeseth, A.S., Jin, L., Ellis, J., Holloway, M.K., Munshi, S., Allison, T., Hazuda, D., Simon, A.J., Graham, S.L., Vacca, J.P. Macrocyclic inhibitors of beta-secretase: functional activity in an animal model. J Med Chem. 49 (21):  6147-50 (2006). Erratum in: J Med Chem. 49 (24): 7252 (2006). Wu, Guoxin [added], Crouthamel, Michelle [added].
  30. Majercak, J., Ray, W.J., Espeseth, A., Simon, A., Shi, X.P., Wolffe, C., Getty, K., Marine, S., Stec, E., Ferrer, M., Strulovici, B., Bartz, S., Gates, A., Xu, M., Huang, Q., Ma, L., Shughrue, P., Burchard, J., Colussi, D., Pietrak, B., Kahana, J., Beher, D., Rosahl, T., Shearman, M., Hazuda, D., Sachs, A.B., Koblan, K.S., Seabrook, G.R., Stone, D.J. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A. 103 (47): 17967-72  (2006).
  31. Rajapakse, H.A., Nantermet, P.G., Selnick, H.G., Munshi, S., McGaughey, G.B., Lindsley, S.R., Young, M.B., Lai, M.T., Espeseth, A.S., Shi, X.P., Colussi, D., Pietrak, B., Crouthamel, M.C., Tugusheva, K., Huang, Q., Xu, M., Simon, A.J., Kuo, L., Hazuda, D.J., Graham, S., Vacca, J.P. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1). J Med Chem. 49 (25): 7270-3 (2006).
  32. Stauffer, S.R., Stanton, M.G., Gregro, A.R., Steinbeiser, M.A., Shaffer, J.R., Nantermet, P.G., Barrow, J.C., Rittle, K.E., Collusi, D., Espeseth, A.S., Lai, M.T., Pietrak, B.L., Holloway, M.K., McGaughey, G.B., Munshi, S.K., Hochman, J.H., Simon, A.J., Selnick, H.G., Graham, S.L., Vacca, J.P. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. Bioorg Med Chem Lett. 17 (6): 1788-92 (2007).
  33. Stone, D.J., Marine, S., Majercak, J., Ray, W.J., Espeseth, A., Simon, A., Ferrer, M. High-throughput screening by RNA interference: control of two distinct types of variance. Cell Cycle 6 (8): 898-901 (2007).
  34. Barrow, J.C., Rittle, K.E., Ngo, P.L., Selnick, H.G., Graham, S.L., Pitzenberger, S.M., McGaughey, G.B., Colussi, D., Lai, M.T., Huang, Q., Tugusheva, K., Espeseth, A.S., Simon, A.J., Munshi, S.K., Vacca, J.P. Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1. ChemMedChem. 2 (7): 995-9 (2007).
  35. Lindsley, S.R., Moore, K.P., Rajapakse, H.A., Selnick, H.G., Young, M.B., Zhu, H., Munshi, S., Kuo, L., McGaughey, G.B., Colussi, D., Crouthamel, M.C., Lai, M.T., Pietrak, B., Price, E.A., Sankaranarayanan, S., Simon, A.J., Seabrook, G.R., Hazuda, D.J., Pudvah, N.T., Hochman, J.H., Graham, S.L., Vacca, J.P., Nantermet, P.G. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg Med Chem Lett. 17 (14): 4057-61 (2007).
  36. Stanton, M.G., Stauffer, S.R., Gregro, A.R., Steinbeiser, M., Nantermet, P., Sankaranarayanan, S., Price, E.A., Wu, G., Crouthamel, M.C., Ellis, J., Lai, M.T., Espeseth, A.S., Shi, X.P., Jin, L., Colussi, D., Pietrak, B., Huang, Q., Xu, M., Simon, A.J., Graham, S.L., Vacca, J.P., Selnick, H. Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid. J Med Chem. 50 (15): 3431-3 (2007).
  37. Moore, K.P., Zhu, H., Rajapakse, H.A., McGaughey, G.B., Colussi, D., Price, E.A., Sankaranarayanan, S., Simon, A.J., Pudvah, N.T., Hochman, J.H., Allison, T., Munshi, S.K., Graham, S.L., Vacca, J.P., Nantermet, P.G. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg Med Chem Lett. 17 (21): 5831-5 (2007).
  38. Sankaranarayanan, S., Price, E.A., Wu, G., Crouthamel, M.C., Shi, X.P., Tugusheva, K., Tyler, K.X., Kahana, J., Ellis, J., Jin, L., Steele, T., Stachel, S., Coburn, C., Simon, A.J.  In vivo beta-secretase 1 inhibition leads to brain Aβ lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1. J Pharmacol Exp Ther. 324 (3): 957-69 (2008).
  39. Simon, A.J., Casimiro, D.R., Finnefrock, A.C., Davies, M.E., Tang, A., Chen, M., Chastain, M., Kath, G.S., Chen, L., Shiver, J.W. Enhanced in vivo transgene expression and immunogenicity from plasmid vectors following electrostimulation in rodents and primates. Vaccine. 26 (40): 5202-9 (2008).
  40. Wu, G., Sankaranarayanan, S., Tugusheva, K., Kahana, J., Seabrook, G., Shi, X.P., King, E., Devanarayan, V., Cook, J.J., Simon A.J. Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects. Clin Biochem. 41(12): 986-96 (2008).
  41. Zetterberg, H., Andreasson, U., Hansson, O., Wu, G., Sankaranarayanan, S., Andersson, M.E., Buchhave, P., Londos, E., Umek, R.M., Minthon, L., Simon, A.J., Blennow, K. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol. 65 (8): 1102-7 (2008).
  42. Barrow, J.C., Stauffer, S.R., Rittle, K.E., Ngo, P.L., Yang, Z., Selnick, H.G., Graham, S.L., Munshi, S., McGaughey, G.B., Holloway, M.K., Simon, A.J., Price, E.A., Sankaranarayanan, S., Colussi, D., Tugusheva, K., Lai, M.T., Espeseth, A.S., Xu, M., Huang, Q., Wolfe, A., Pietrak, B., Zuck, P., Levorse, D.A., Hazuda, D., Vacca, J.P. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. J Med Chem. 51 (20): 6259-62, (2008).
  43. Sankaranarayanan, S., Holahan, M.A., Colussi, D., Crouthamel, M.C., Devanarayan, V., Ellis, J., Espeseth, A., Gates, A.T., Graham, S.L., Gregro, A.R., Hazuda, D., Hochman, J.H., Holloway, K., Jin, L., Kahana, J., Lai, M.T., Lineberger, J., McGaughey, G., Moore, K.P., Nantermet, P., Pietrak, B., Price, E.A., Rajapakse, H., Stauffer, S., Steinbeiser, M.A., Seabrook, G., Selnick, H.G., Shi, X.P., Stanton, M.G., Swestock, J., Tugusheva, K., Tyler, K.X., Vacca, J.P., Wong, J., Wu, G., Xu, M., Cook, J.J., Simon, A.J. First demonstration of CSF and plasma Aβ lowering with oral administration of a BACE1 inhibitor in nonhuman primates. J Pharmacol Exp Ther. 328 (1): 131-40, Jan (2009).
  44. Nantermet, P.G., Rajapakse, H.A., Stanton, M.G., Stauffer, S.R., Barrow, J.C., Gregro, A.R., Moore, K.P., Steinbeiser, M.A., Swestock, J., Selnick., H.G., Graham, S.L., McGaughey, G.B., Colussi, D., Lai, M.T., Sankaranarayanan, S., Simon, A.J., Munshi, S., Cook, J.J., Holahan, M.A., Michener, M.S., Vacca, J.P. Evolution of Tertiary Carbinamine BACE-1 Inhibitors: Aβ reduction in Rhesus CSF upon oral dosing, ChemMedChem.  4 (1): 37-40, Jan (2009).
  45. Mattsson, N., Axelsson, M, Haghighi, S, Malmeström, C, Wu, G, Anckarsäter, R, Sankaranarayanan, S, Andreasson, U, Fredrikson, S, Gundersen, A, Johnsen, L, Fladby, T, Tarkowski, A, Trysberg, E, Wallin, A, Anckarsäter, H, Lycke, J, Andersen, O, Simon, A.J., Blennow, K., Zetterberg, H. Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mult Scler. 15 (4): 448-54, Apr (2009).
  46. Shaw, L.M., Vanderstichele, H., Knapik-Czajka, M., Clark, C.M., Aisen, P.S., Petersen, R.C., Blennow, K., Soares, H., Simon, A., Lewczuk, P., Dean, R., Siemers, E., Potter, W., Lee, V.M., Trojanowski, J.Q.; Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol. 65 (4): 403-13, Apr. (2009).
  47. Stachel SJ, Coburn CA, Rush D, Jones KL, Zhu H, Rajapakse H, Graham SL, Simon A, Katharine Holloway M, Allison TJ, Munshi SK, Espeseth AS, Zuck P, Colussi D, Wolfe A, Pietrak BL, Lai MT, Vacca JP. Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1. Bioorg Med Chem Lett. 19 (11): 2977-80, Jun. (2009).
  48. Portelius, E., Price, E., Brinkmalm, G., Stiteler, M., Olsson, M., Persson, R., Westman-Brinkmalm, A., Zetterberg, H., Simon, A.J., Blennow, K. A novel pathway for amyloid precursor protein processing. Neurobiol Aging. 32 (6):1090-8, Jun (2011).
  49. Paweletz CP, Wiener MC, Bondarenko AY, Yates NA, Song Q, Liaw A, Lee AY, Hunt BT, Henle ES, Meng F, Sleph HF, Holahan M, Sankaranarayanan S, Simon AJ, Settlage RE, Sachs JR, Shearman M, Sachs AB, Cook JJ, Hendrickson RC. Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high-resolution differential mass spectrometry. J Proteome Res. 9 (3):1392-401, Mar (2010).
  50. Zhu H, Young MB, Nantermet PG, Graham SL, Colussi D, Lai MT, Pietrak B, Price EA, Sankaranarayanan S, Shi XP, Tugusheva K, Holahan MA, Michener MS, Cook JJ, Simon A, Hazuda DJ, Vacca JP, Rajapakse HA. Rapid P1 SAR of brain-penetrant tertiary carbinamine derived BACE inhibitors. Bioorg Med Chem Lett. 20 (5):1779-82, Mar. (2010).
  51. Rajapakse HA, Nantermet PG, Selnick HG, Barrow JC, McGaughey GB, Munshi S, Lindsley SR, Young MB, Ngo PL, Holloway MK, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. SAR of tertiary carbinamine derived BACE1 inhibitors: the role of aspartate ligand amine pKa in enzyme inhibition. Bioorg Med Chem Lett. 20 (6):1885-9, Mar (2010).
  52. Das R, Nachbar RB, Edelstein-Keshet L, Saltzman JS, Wiener MC, Bagchi A, Bailey J, Coombs D, Simon AJ, Hargreaves RJ, Cook JJ. Modeling effect of a γ-secretase inhibitor on amyloid-β dynamics reveals significant role of an amyloid clearance mechanism. Bull Math Biol. 73 (1):230-47, Jan. (2011).
  53. Trojanowski JQ, Vandeerstichele H, Korecka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter WZ, Weiner MW, Jack CR Jr, Jagust W, Toga AW, Lee VM, Shaw LM; Alzheimer's Disease Neuroimaging Initiative.Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects. Alzheimers Dement. 6 (3):230-8. Review, May (2010).
  54. Cook JJ, Wildsmith KR, Gilberto DB, Holahan MA, Kinney GG, Mathers PD, Michener MS, Price EA, Shearman MS, Simon AJ, Wang JX, Wu G, Yarasheski KE, Bateman RJ. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 30 (19):6743-50, May (2010).
  55. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 68 (2):220-30, Aug (2010).
  56. Shaw LM, Vanderstichele H, Knapik-Czajka M, Figurski M, Coart E, Blennow K, Soares H, Simon AJ, Lewczuk P, Dean RA, Siemers E, Potter W, Lee VM, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathol. 121 (5):597-609, May (2011).
  57. Ohrfelt A, Andreasson U, Simon A, Zetterberg H, Edman A, Potter W, Holder D, Devanarayan V, Seeburger J, Smith AD, Blennow K, Wallin A. Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease. Dement Geriatr Cogn Dis Extra. 1 (1):31-42, Jan. (2011).
  58. Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex. J Neurosci Res. 89 (6):822-32, Jun. (2011).
  59. Wu G, Sankaranarayanan S, Montgomery DL, Simon AJ, An Z, Savage MJ. Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product. Protein Cell. 2 (7):573-84, Jul. (2011).
  60. Shapiro JS, Stiteler M, Wu G, Price EA, Simon AJ, Sankaranarayanan S. Cisterna magna cannulated repeated CSF sampling rat model - effects of a gamma-secretase inhibitor on Aβ levels. J Neurosci Methods. 205 (1):36-44, Mar 30 (2012), Epub. Dec. (2011).
  61. Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, Wan HI, Trojanowski JQ, Shaw LM; Biomarkers Consortium Alzheimer's Disease Plasma Proteomics Project. Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer disease. Arch Neurol. 2012 Oct; 69 (10):1310-7.
  62. Mattsson N, Zegers I, Andreasson U, Bjerke M, Blankenstein MA, Bowser R, Carrillo MC, Gobom J, Heath T, Jenkins R, Jeromin A, Kaplow J, Kidd D, Laterza OF, Lockhart A, Lunn MP, Martone RL, Mills K, Pannee J, Ratcliffe M, Shaw LM, Simon AJ, Soares H, Teunissen CE, Verbeek MM, Umek RM, Vanderstichele H, Zetterberg H, Blennow K, Portelius E. Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.  Biomark Med. 2012 Aug; 6 (4):409-17.
  63. Wu G, Sankaranarayanan S, Wong J, Tugusheva K, Michener MS, Shi X, Cook JJ, Simon AJ, Savage MJ. Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease. J Neurosci Res. 2012 Dec; 90 (12):2247-58.
  64. Llano DA, Devanarayan V, Simon AJ; The Alzheimer’s Disease Neuroimaging Initiative (ADNI).Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease. Alzheimer Dis Assoc Disord. 2013 Jul-Sep; 27 (3):233-43.
  65. Ghorbanian P, Devilbiss DM, Simon AJ, Bernstein A, Hess T, Ashrafiuon H. Discrete wavelet transform EEG features of Alzheimer's disease in activated states. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug: 2937-40.
  66. Ghorbanian P, Devilbiss DM, Verma A, Bernstein A, Hess T, Simon, AJ, Ashrafiuon H. Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform. Annals of Biomed Engineer 2013; 41 (6):1243-1257.
  67. Ostrovsky A, Deen N, Simon A, Mate K. A Framework for Selecting Digital Health Technology. IHI Innovation Report. Cambridge, MA: Institute for Healthcare Improvement; June 2014. (Available at www.ihi.org ).
  68. Ghorbanian P, Devilbiss DM, Hess T, Bernstein A, Simon, AJ, Ashrafiuon H. Exploration of EEG features of Alzheimer's disease using continuous wavelet transform. Med Biol Eng Comput, Sept. 2015; 53 (9): 843-855 (published online 12 April 2015).
  69. Seeburger JL, Holder DJ, Combrinck M, Joachim C, Laterza O, Tanen M, Dallob A, Chappell D, Snyder K, Flynn M, Simon A, Modur V, Potter WZ, Wilcock G, Savage MJ, Smith AD. Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort. J Alzheimers Dis. 2015; 44 (2): 525-39.
  70. Egbertson M, McGaughey GB, Pitzenberger SM, Stauffer SR, Coburn CA, Stachel SJ, Yang W, Barrow JC, Neilson LA, McWherter M, Perlow D, Fahr B, Munshi S, Allison TJ, Holloway K, Selnick HG, Yang Z, Swestock J, Simon AJ, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Pietrak B, Haugabook S, Jin L, Chen IW, Holahan M, Stranieri-Michener M, Cook JJ, Vacca J, Graham SL. Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency; Bioorg Med Chem Lett. 2015 Nov 1; 25 (21):4812-9.
  71. Devilbiss DM, Etnoyer-Slaski JL, Dunn E, Dussourd CR, Kothare MV, Martino SJ, Simon AJ. Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion. J Healthc Eng. 2019 Apr 30; 2019:4794637.
  72. Fisher CK, Smith AM, Walsh JR; Coalition Against Major Diseases; Abbott, Alliance for Aging Research, Alzheimer’s Association, Alzheimer’s Foundation of America, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Critical Path Institute, CHDI Foundation, Inc., Eli Lilly and Company, F. Hoffmann-La Roche Ltd, Forest Research Institute, Genentech, Inc., GlaxoSmithKline, Johnson & Johnson, National Health Council, Novartis Pharmaceuticals Corporation, Parkinson’s Action Network, Parkinson’s Disease Foundation, Pfizer, Inc., sanofi-aventis. Collaborating Organizations: Clinical Data Interchange Standards Consortium (CDISC), Ephibian, Metrum Institute.
    Machine learning for comprehensive forecasting of Alzheimer's Disease progression. Sci Rep. 2019 Sep 20; 9(1):13622.


Issued Patents


  1. Simon, A. J. System and method for assessing the performance of a pharmaceutical agent delivery system. Filed May 22, 2000, U.S. Patent Application No. 09/862,850. Issued:  US 6,928,318, Aug. 9, 2005.
  2. Hazuda, D. J., Chen-Dodson, E., Lai, M-T., Xu, M., Shi, X-P., Simon, A. J., Li, Y., Register, R. Assays using amyloid precursor proteins with modified beta-secretase cleavage sites to monitor beta-secretase activity. Application No. US2003/427208A, Filed Apr. 30, 2003, Published Mar. 27, 2007. Issued:  US 7,196,163, Mar. 27, 2007.
  3. Simon, A. J. Molecular combing of macromolecules through the action of a meniscus on highly specific surfaces. Filed August 9, 1995, PCT/US96/13081. Extended August 9, 1996, WO 97/06278. Issued:  EP 0 843 739, Nov. 7, 2007.
  4. Chen, R. Z., Simon, A. J., Vogt, T. F. Transgenic mouse having an amyloid precursor protein with a modified beta-secretase cleavage site. Filed November 7, 2003. Application No. US2005/558656A, Filed Nov. 29, 2005. Issued:  US 7,432,414, Oct. 7, 2008.
  5. Simon, A. J. Brain-computer interface test battery for the physiological assessment of nervous system health. Filed December 15, 2011, Priority: December 31, 2009, U.S. Application No. 13/ 327,034. Issued:  US 9,357,941, June 7, 2016.
  6. Simon, A. J. and Devilbiss, D.M. Systems and methods for the physiological assessment of brain health and the remote quality control of EEG systems. Filed July 13, 2012 as 2.PCT/US2012/046723, filed by Cerora Inc. Publication WO2013/012739 Jan. 24, 2013. Australian patent application AU 2012284246 was granted on 8 June 2017.
  7. Simon, A.J. and Kath, G.S. Form factors for the multi-modal physiological assessment of brain health. Filed March 6, 2014 as 3.PCT/US2014/021247, by Cerora Inc. Publication WO2014138414 Sept. 12, 2014. Australian patent application AU 2014225626 was accepted on 24 January 2018.